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Working Groups
The Working Groups include several Case Definition Working Groups, the Implementation Working Group, and a Neonatal Immunization Working Group.
The Case Definition Working Groups develop standardized case definitions and guidelines for data collection, analysis, and presentation of AEFI.
The working group coordinators with the assistance of the Brighton Collaboration Coordinators ascertain that the work within the working group is being carried out in accordance with the policies and processes of the Collaboration. The working group coordinators see that the objectives of the working groups are met within set time lines. The working group coordinators are selected by the Brighton Collaboration general coordinators.
Working group team leaders serve as chair of their working group. Working groups work as multidisciplinary teams consisting of 5 - 20+ volunteers with relevant experience in patient care, public health, clinical trials, safety surveillance and safety assessment from developed and developing countries. Should necessary professional or geographical expertise be underrepresented in a working group, efforts will be made to recruit additional volunteers. Volunteers are actively sought by the Secretariat, can be recommended, or can volunteer themselves. Volunteers may participate in more than one working group and are listed in the respective working group link.
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Neonatal Immunization Working Group
The 1st International Neonatal Vaccination Workshop was held March 2-4, 2004, in Virginia to explore the immunology, safety, and strategies to expand protection of neonates against vaccine preventable diseases. The participants found it difficult to compare studies conducted in different settings, and critical information was lacking.
One of the conclusions of the Workshop was that vaccine trials in neonates will require standardization of information. The Brighton Collaboration was asked by the World Health Organization (WHO) to take on the task of developing a template of information required for vaccine trials among neonates (and infants), including potential adverse events following immunization. A neonatal working group of international experts in vaccinology, immunology, and infectious diseases formed in 2004 to take on this work.
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Case Definition and Guidelines Working Groups
One case definition working group has begun in 2005, Guillain-Barré Syndrome.
One case definition working group began in 2004, aseptic meningitis.
Eleven case definition working groups began in 2003, namely anaphylaxis , fatigue state, encephalitis, local reactions (abscess, cellulitis, induration and swelling at injection site), thrombocytopenia, rash, unexplained sudden infant death, and several vaccinia AEFI (eczema vaccinatum, progressive vaccinia, generalized vaccinia, robust take, and inadvertent inoculation).
Six working groups began in 2001, including persistent crying, fever, hypotonic-hyporesponsive episode, intussusception, local reactions (nodule at injection site), and generalized convulsive seizure. The respective documents were finalized in 2003 and published in 2004.
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Method Working Group
The Method Working Group began in 2002 and is developing generic guidelines for data collection, analysis, and presentation for separate use in surveillance systems and clinical trials.
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